According to the latest research, the burden of damaged cells, often known as senescent cells; can be possibly reduced and facilitate lifespan expansion and improved health. This is highly feasible even when treatment has come late in life. The studies used lab mice which were treated with Fisetin, a flavonoid component available in a variety of fruits and vegetables. In the studies, the effect of Fisetin showed substantial improvements on health and lifespan in the mice.
Overview of Fisetin on Human Health
Aging usually results in the accumulation of damaged cells. Damaged cells often start aging when they reach particular levels of damage. This is usually referred to as cellular senescence. Senescence process causes the release of inflammatory factors, which instruct the immune system to get rid of the damaged cells.
Immune System’s Response in Aging
For young people, their immune system is often still very active hence healthy enough to constantly get rid of the damaged cells. But as we get older and start aging, the immune system becomes ineffective in removing damaged cells from our bodies. This results in accumulation of the damaged cells, which cause low level inflammation. This inflammation results in the release of enzymes that degrade our tissues.
Thanks to the work of researchers, Fisetin was discovered to reduce damaged cells in our bodies. This was through pre-clinical tests on mice heading towards the end of life. In the tests, this seno-therapeutic compound was seen to improve both the health and lifespans in the mice.
What Makes Fisetin Interesting?
The above results are an indication that our periods of health, otherwise lifespan; can be extended even when we are almost at the end of life. Even so, one would wonder: why are we just coming to the realization of this now? The truth is that science keeps evolving.
Initially, there were critical limitations that prevented how researchers could study the specific impact of drugs on different tissues and different cells in the body during aging. Thanks to the advancements that have been witnessed in modern science, augmented by technological advancements, scientists can now identify how a particular treatment is attacking senescence cells.
Senescence is known to account for numerous age-related conditions including cancer. When we get old, senescent cells often accumulate in sites where chronic age-related diseases are present. When we use Fisetin or its products, it will help attack the senescent cells at the pathogenesis sites of chronic diseases and lead to a significant reduction in senescent cell burden. This reduction will effectively lead to:
• Reduced inflammation
• Decreased macromolecular dysfunction
• Improved function of progenitor cells
The research further proved that when fisetin is pitted against flavonoids, it senotherapeutic potency was unmatched. This compound is naturally available in common foods that the elderly could leverage on to enhance their health. In addition, the compound is available as a dietary supplement that can be taken orally.
The best thing is there have been no adverse side effects reported to using fisetin. The continued use of this compound can result in substantial health improvements in elderly patients.